What’s the molecules telling?

A 65-year-old male presented with a nonhealing ulcer over the pinna of the right ear for 5 months. A biopsy from the lesion was done and the following is the report. Carcinoma with basaloid features and pigmentation – biopsy right pinna. Immunostaining: P63 – diffuse strong positivity. P40 – diffuse moderate positivity. BerEP4 – negative.

Temporal bone cancer staging systems

Staging of cancers is essential for patient counseling, treatment planning, predict treatment outcome and survival. Most commonly followed staging system for head and neck malignancies is the Tumor, Node, Metastasis (TNM staging system) by the American Joint Committee on Cancer (AJCC). Because of the relative rarity of temporal bone cancers, a universally accepted temporal bone